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Platelet-Rich Fibrin (PRF) — Biological Support for Healing and Regeneration
PRF (platelet-rich fibrin) is used as a supportive therapy in procedures such as extractions, periodontal treatment, and selected aesthetic interventions. It is an autologous biomaterial derived from the patient’s blood, rich in growth factors that support tissue healing and regeneration.
This technique is integrated into our clinical protocols to enhance healing response and improve treatment conditions in a controlled and biologically aligned manner.
A simple, clinically effective approach
The PRF Process — Simple, Autologous, and Integrated
A small sample of blood — approximately 10 ml — is collected and processed through centrifugation to obtain platelet-rich fibrin (PRF). The PRF is then applied directly to the extraction site or soft tissues to support healing and tissue regeneration.
The entire process is completed within approximately 10 to 15 minutes and is performed as an integrated part of the overall clinical procedure — with no additional appointments required.
What Is PRF and How Is It Used?
Platelet-rich fibrin (PRF) is an autologous biomaterial derived from the patient’s own blood, containing a high concentration of platelets, leukocytes, and growth factors that support tissue healing and regeneration.
At Yiannikos Centre for Holistic Dentistry, PRF is integrated into our clinical protocols as a supportive therapy — applied across a range of procedures where an enhanced healing response is clinically beneficial. It supports the regeneration of both soft tissues and bone, and is particularly indicated in the following cases:
- Immediately following tooth extraction
- During dental implant placement
- In the management of periodontal conditions, including gingivitis and periodontitis
- In selected aesthetic procedures involving soft tissue and root exposure
Indications for PRF Application
PRF — Clinical Indications and Patient Suitability
PRF may be considered as a supportive therapy in patients where enhanced healing conditions are desirable — particularly in individuals with systemic or local factors that may influence tissue repair.
Clinical indications may include:
- Patients with diabetes
- Smokers
- Patients with vitamin deficiencies
- Individuals with cardiovascular conditions
- Patients receiving antiplatelet or anticoagulant therapy — including aspirin
- Patients undergoing treatment for osteoporosis, including bisphosphonate therapy
- Patients with a history of head and neck radiotherapy
In these situations, healing response may be affected. PRF can be incorporated into the treatment plan to support tissue repair and recovery — always based on individual clinical assessment and the specific needs of each patient.
Clinical Benefits of PRF
- Supports improved control of bleeding at the treatment site
- May help reduce post-operative swelling
- Contributes to reduced discomfort during the healing phase
- Supports a more efficient and predictable healing response
- May reduce reliance on pharmacological intervention in selected cases
- Integrates seamlessly into minimally invasive, controlled treatment protocols
- Focused on long-term clinical value through optimised healing conditions
- As a fully autologous material, PRF is well tolerated and associated with a low risk of adverse reactions
PRF at Yiannikos Centre for Holistic Dentistry
PRF is applied based on clinical indication and integrated into a structured, biologically guided treatment approach — always with a focus on safety, biological compatibility, and long-term outcomes.
Dr. Anna Maria Yiannikos and Eirini Fragkiadaki have both completed advanced training in PRF protocols, including clinical education with Joseph Choukroun — the originator of the technique.
Frequently asked questions
Why do we use it?
The PRF process can:
• Stop bleeding
• Significantly reduce swelling
• Help alleviate pain
• Eliminate dry socket
• Preserve the dimensions of gums and bones
How does the PRF protocol work?
Thanks to our state-of-the-art technology, our Cyprus dental practice can achieve this entire process. At Yiannikos Centre for Holistic Dentistry, we use the safest and most up-to-date dental materials and techniques. Therefore, we are proud to share that we use PRF technology for this process.
What is the actual process?
• First, we collect a small blood sample (10ml)from the patient
• Then it spins in a centrifuge to break up the components
• We then place the resulting material over the extraction site or inside the gum
This process results in a biocompatible method for ensuring optimal oral health.
Is the treatment covered by insurance?
It's best to check with your insurance provider.
Why do we use PRF in biological dentistry?
We use this treatment as a holistic approach to speeding up the healing process and reducing any pain you might get from more invasive dental treatments. The process only adds 10-15 extra minutes on top of treatment but significantly quickens the healing time. With this method, our patients can receive the most comfortable and accommodating dental care we can offer.
In which situations do we apply PRF in dentistry?
We apply this process to treatments such as:
• Extractions (surgical and non-surgical)
• Implant procedures (This is especially useful during this treatment as it typically involves a lengthy healing time!)
• Treating gum disease
• Resolving gum recession
What are the benefits of PRF?
As a holistic/biological dentist, we always want to provide the best and most comfortable treatment options for our patients, especially those who naturally have trouble healing. That's why we incorporate this process into our more invasive procedures.
The PRF method is exceptionally beneficial for patients who:
• Are diabetic
• Smoke
• Have a vitamin D deficiency
• Have high cholesterol
• Have cardiovascular disease
• Have undergone radiotherapy on their head or neck
Take bisphosphonates or daily aspirin